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Project_08 Q21 StudyTitle Probing the parameters of sensitization and compulsive checking: characteristics of behavioral measures during pathogenesis of compulsive behavior
| Description: | This study (Q21) is one of a series of studies performed in the Szechtman lab at McMaster University and deposited in the FRDR public repository as a collection under the name "A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection". This collection as a whole constitutes a big dataset containing raw data objects of video, track, and path plot records of rats exploring for 55 minutes a large testing environment in a standardized paradigm during chronic treatment with psychostimulant drugs; for details of this big dataset see, https://www.frdr-dfdr.ca/repo/collection/szechtmanlab. The historical context for study Q21 was Project_08 entitled: "Probing the parameters of sensitization and compulsive checking". Title of experiment in Q21 was "Development and temporal organization of compulsive checking induced by repeated injections of QNP (0.5 mg/kg)". This experiment was embedded in a larger study, Project_09 entitled: "Probing the environmental modulation of sensitization and compulsive checking", where the title of the experiment was "Effect of separating pups from maternal nest for 15 or 180 min on postnatal days 2 to 15 on the development of compulsive checking induced by repeated injections of quinpirole in adult male rats". |
| Authors: | Szechtman, Henry; McMaster University;  0000-0003-3986-4482Dvorkin-Gheva, Anna; McMaster University; 0000-0001-7295-7440Perreault, Melissa L.; McMaster University; University of Guelph; 0000-0002-5775-8950 |
| Keywords: | animal model obsessive compulsive disorder OCD compulsive checking behavior exploration locomotion motor activity behavioral sensitization security motivation system male rats Long-Evans open field large testing environment 160x160 cm dopamine receptor agonist chronic treatment with quinpirole (0.5 mg/kg) neonatal stress maternal separation repeated injections of saline vehicle video recording digitized track record plot of routes of locomotion
repeated testing
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repeated trials per rat 13 trials available 431 number of rats 72 |
| Field of Research: | Biological sciences > Neurosciences, biological and chemical aspects > Behavioural neuroscience of reward and motivation
Basic medicine and life sciences > Neurosciences, medical and physiological and health aspects > Neurosciences, medical and health and physiological aspects, not elsewhere classified
Psychology and cognitive sciences > Psychology, social and behavioural aspects > Psychopathology
Psychology and cognitive sciences > Cognitive sciences > Cognitive behaviour
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| Publication Date: | 2021-08-04 |
| Publisher: | Federated Research Data Repository / dépôt fédéré de données de recherche |
| Funder: | Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behavior; MT-12852 Canadian Institutes of Health Research (CIHR); Dopamine, movements, motion and behaviour: Animal model of OCD; MOP-64424 Natural Sciences and Engineering Research Council of Canada (NSERC); RGPIN A0544 |
| URI: | https://doi.org/10.20383/102.0443 |
| Related Identifiers: |
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| Geographic Coverage: | Place Name Health Sciences Centre, McMaster University City Hamilton Province / Province / Territory Ontario Territory Country Canada |
| Geographic Point: | Latitude 43.25978 Longitude -79.91763 |
| Appears in Collections: | A Digital Library of Behavioural Performance in Standardized Conditions - Szechtman Lab Collection |
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Access to this dataset is subject to the following terms:
Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Citation
Szechtman, H., Dvorkin-Gheva, A., Perreault, M. (2021). Project_08 Q21 StudyTitle Probing the parameters of sensitization and compulsive checking: characteristics of behavioral measures during pathogenesis of compulsive behavior. Federated Research Data Repository. https://doi.org/10.20383/102.0443
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